Bull trout and cutthroat are catch-and-release; brook and rainbow trout follow the regional default quota (2 trout/char daily from streams). Single barbless hook applies all year, and the river falls under the regional Apr 1 to Jun 14 stream closure. No powered boats are allowed from the bridge at the south end of Moyie Lake down to the US border, and Irishman Creek, a tributary, is closed to fishing all year. Confirm the current synopsis before you go.

The river rises in southeastern BC and flows northeast, then east, then south through Moyie Lake before bending south and west past Yahk on its roughly 148 km (92-mile) run to the Kootenai River in Idaho. Below the lake, Little Moyie River joins from the right bank, along with Sunrise, Sundown, Irishman, Englishman and Hawkins creeks, the last of which itself gathers Canuck Creek and America Creek. Moyie Falls, downstream of the lake, blocks upstream fish passage from the lower river, which is why the kokanee now established in Moyie Lake and the upper river were introduced there in the 1940s rather than arriving on their own. A hydroelectric dam has stood near the falls since 1949, after an earlier structure, built in 1923, was destroyed by flooding in 1925.

The river carries a wide, gentle profile (median width ~26.2 m, moderate to wide; median gradient ~0.32%, very gentle; peak mean-annual discharge ~13.2 m³/s, moderate flow), the kind of open water that reads well and covers ground quickly with a dry-dropper rig. Brook and rainbow trout are the everyday catch, and it shares the same summer and fall stonefly, caddis and callibaetis hatches as the St. Mary, Bull, Skookumchuck and Kootenay rivers. Start summer on attractors, a Stimulator or Royal Wulff, move to hoppers and terrestrials on a Chubby Chernobyl through August and September, then fish Blue-Winged Olives and Green Drakes under an Adams into fall. Round out the box with an Elk Hair Caddis, Hare's Ear, Pheasant Tail, Prince and Pat's Rubber Legs for when the fish are down. A small subalpine lake near the headwaters, close to the community of Moyie, is a short hike-in option for good-sized westslope cutthroat on dry flies.

Public access is limited to the day-use picnic area at Yahk Provincial Park, beside the river in Yahk; no other trailhead or launch is confirmed. Two Pump Paul's in Yahk sells fishing licences for anglers working the river. No powered boats are allowed from the bridge at the south end of Moyie Lake down to the US border, and the river crosses into Idaho at the Kingsgate/Eastport border crossing, where BC regulations no longer apply.